{"product_id":"pro-resolve-omega-60-softgels","title":"Pro-Resolve Omega 60 softgels","description":"\u003cp\u003e\u003cstrong\u003eSuggested Use:\u003c\/strong\u003e 1 softgel capsule daily, with a meal, or as directed by a health professional.\u003c\/p\u003e\n\u003cdiv class=\"clear\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"ProductsDesc\"\u003e\n\u003cstrong\u003ePro-Resolve Omega\u003c\/strong\u003e – Specialized Pro-Resolving Mediators (SPMs) to enhance and sustain immune resolution and restoration of homeostasis‡\u003c\/div\u003e\n\u003cdiv class=\"ProductsDescExtra\"\u003eVERIFIABLE SCIENCE Pro-Resolve Omega offers a unique blend of marine oils concentrated in Specialized Pro-Resolving Mediators (SPMs). SPMs are a group of compounds derived from marine oils, and play a critical role in resolution of the inflammatory process, including cytokine production and immune cell recruitment and function. Not all inflammation is associated with disease states. The body’s inflammation response to life’s occasional, normal stressors is important for optimal health. The body produces SPMs from fish oil; however, this multi-step process is inefficient and can be compromised. In two studies involving healthy subjects, supplementation with 4-17 grams of fish oil daily did not produce significant increases in SPMs.1 Different families of resolvins are derived from EPA, DHA, DPA, and AA, and each mediator exerts unique biological actions, such as regulating platelet activation (resolvin E1), regulating immune function (protectins), or promoting tissue health (maresins). Research has focused primarily on the E-series resolvins from 18-HEPE derived from EPA, and the protectins, maresins, and D-series resolvins from 17-HDHA derived from DHA.2 The omega-3 fatty acid DPA (docosapentaenoic acid) is a precursor for T-series resolvins and has long been associated with vascular health. In a pool of 19 studies and over 45,000 individuals, DPA was the long-chain essential fatty acid most associated with cardiovascular health.3 Mechanistic examinations suggest that 15-lipoxygenase (15-LOX), an enzyme that converts DHA and EPA to SPMs, may be critical for SPM production. While levels of EPA and DHA were comparable in immune cells isolated from subjects supplemented with fish oil, cells from obese subjects had compromised levels of 15-LOX and SPM production.4 Another study indicated that metabolic factors may influence levels of SPM precursors in response to fish oil supplementation.5 In healthy volunteers, supplementation of fish oil with SPM increased immune cell efficacy and decreased expression of adhesion molecules and platelet activation.6‡\u003c\/div\u003e\n\u003cdiv class=\"ProductsDescExtra\"\u003e\u003c\/div\u003e\n\u003cdiv class=\"ProductsDescExtra\"\u003e\n\u003cmeta charset=\"UTF-8\"\u003e\n\u003cspan class=\"title-big\"\u003eSupplement Facts:\u003c\/span\u003e\u003cspan\u003e\u003c\/span\u003e\n\u003cdiv class=\"suggested_use\"\u003e\n\u003cb\u003eSuggested Use: \u003c\/b\u003e1 softgel capsule daily, with a meal, or as directed by a health professional.\u003c\/div\u003e\n\u003cdiv class=\"description_header\"\u003eone softgel capsule contains:\u003c\/div\u003e\n\u003ctable class=\"product_ingredients\"\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth class=\"h_c1\"\u003eINGREDIENTS\u003c\/th\u003e\n\u003cth class=\"h_c2\"\u003e\u003cb\u003eAMT\u003c\/b\u003e\u003c\/th\u003e\n\u003cth class=\"h_c3\"\u003e\u003cb\u003e%DV\u003c\/b\u003e\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr valign=\"top\"\u003e\n\u003ctd class=\"h_c1\"\u003eCalories\u003c\/td\u003e\n\u003ctd class=\"h_c2\"\u003e10\u003c\/td\u003e\n\u003ctd class=\"h_c3\"\u003e-\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr valign=\"top\"\u003e\n\u003ctd class=\"h_c1\"\u003eTotal Fat\u003c\/td\u003e\n\u003ctd class=\"h_c2\"\u003e1 g\u003c\/td\u003e\n\u003ctd class=\"h_c3\"\u003e-\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr valign=\"top\"\u003e\n\u003ctd class=\"h_c1\"\u003eCholesterol\u003c\/td\u003e\n\u003ctd class=\"h_c2\"\u003e5 mg\u003c\/td\u003e\n\u003ctd class=\"h_c3\"\u003e-\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr valign=\"top\"\u003e\n\u003ctd class=\"h_c1\"\u003eMarine oil concentrate (from anchovy, sardine herring, mackerel, squid)\u003c\/td\u003e\n\u003ctd class=\"h_c2\"\u003e1090 mg\u003c\/td\u003e\n\u003ctd class=\"h_c3\"\u003e-\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr valign=\"top\"\u003e\n\u003ctd class=\"h_c1\"\u003eProviding: Total omega-3 fatty acids\u003c\/td\u003e\n\u003ctd class=\"h_c2\"\u003e560 mg\u003c\/td\u003e\n\u003ctd class=\"h_c3\"\u003e-\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr valign=\"top\"\u003e\n\u003ctd class=\"h_c1\"\u003eEPA (eicosapentaenoic acid)\u003c\/td\u003e\n\u003ctd class=\"h_c2\"\u003e225 mg\u003c\/td\u003e\n\u003ctd class=\"h_c3\"\u003e-\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr valign=\"top\"\u003e\n\u003ctd class=\"h_c1\"\u003eDHA (docosahexaenoic acid)\u003c\/td\u003e\n\u003ctd class=\"h_c2\"\u003e200 mg\u003c\/td\u003e\n\u003ctd class=\"h_c3\"\u003e-\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr valign=\"top\"\u003e\n\u003ctd class=\"h_c1\"\u003eDPA (docosapentaenoic acid)\u003c\/td\u003e\n\u003ctd class=\"h_c2\"\u003e45 mg\u003c\/td\u003e\n\u003ctd class=\"h_c3\"\u003e-\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr valign=\"top\"\u003e\n\u003ctd class=\"h_c1\"\u003eSPMs\u003c\/td\u003e\n\u003ctd class=\"h_c2\"\u003e300 mcg\u003c\/td\u003e\n\u003ctd class=\"h_c3\"\u003e-\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr valign=\"top\"\u003e\n\u003ctd class=\"h_c1\"\u003e(including 18-hydroxyeicosapentaenoic acid (18-HEPE), 17-hydroxydocosahexaenoic acid (17-HDHA), and 14-hydroxydocosahexaenoic acid (14-HDHA))\u003c\/td\u003e\n\u003ctd class=\"h_c2\"\u003e-\u003c\/td\u003e\n\u003ctd class=\"h_c3\"\u003e-\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cdiv class=\"ingredients_other\"\u003e\u003cspan class=\"other_title\"\u003eOther Ingredients: gelatin capsule (gelatin, glycerin, water), natural lemon flavor, natural mixed tocopherolsContains fish (anchovy, sardine, herring, mackerel, squid)\u003c\/span\u003e\u003c\/div\u003e\n\u003cdiv class=\"ingredients_nodv\"\u003e(-) There is no %DV or the manufactuer has not provided this data.\u003c\/div\u003e\n\u003c\/div\u003e","brand":"Pure Encapsulations","offers":[{"title":"Default Title","offer_id":42334098325546,"sku":"","price":80.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1334\/3567\/files\/pro-resolve-omega-pureencapsulations.webp?v=1780028022","url":"https:\/\/metabolicnutrients.com\/products\/pro-resolve-omega-60-softgels","provider":"MetabolicNutrients.com","version":"1.0","type":"link"}